Sibutramine:Works,Dosage and Side effect

Sibutramine:Works,Dosage and Side effect

Sibutramine

Sibutramine is a medication that assists with weight-loss by altering neurotransmitters within the brain. Neurotransmitters are chemicals that are produced and released by nerves in order to communicate with other nerves. Sibutramine blocks the reuptake of the neurotransmitters dopamine, norepinephrine, and serotonin. Blocking the reuptake of neurotransmitters alters the balance of neurotransmitters within the nerve cells and thereby affect nerve function and interaction. Sibutramine is used for weight loss in conjunction with a low calorie diet. , Sibutramine becoming popular as a dietary supplement endorsed as an effective slimming pill.

How does sibutramine works?

Sibutramine offers three types of benefit in weight management: by enhancing weight loss, by improving weight maintenance and by reducing the comorbidities of obesity. The clinical effects of sibutramine are explained through its known mode of action as a serotonin (5-HT) and noradrenaline reuptake inhibitor (SNRI). This dual mechanism of action results in two synergistic physiological effects--a reduction in energy intake and an increase in energy expenditure, which combine to promote and maintain weight loss.

What is the dosage for sibutramine?

Sibutramine is taken once daily, generally in the morning. Therapy usually is started with one 10mg tablet per day. The dose may be increased to 15mg by the physician after several weeks to achieve the desired effect. Doses of up to 60mg have been studied. Sibutramine may be taken with or without food.

What are the side effects of sibutramine?

In general, sibutramine is well-tolerated. The most common side effects have been:
constipation,inability to sleep,headache,dry mouth,abdominal pain,acne,rash,chest pain,anxiety,joint pain,back pain,excitation,depression,sweating,dizziness,drowsiness,changes in taste,irregular or painful menstrual periods,flu-like syndrome,increased cough,muscle pain,nausea,vomiting,neck pain,nervousness,palpitations,tingling of the extremities,sore throat, and sinus congestion.
Abnormal liver tests have been reported in 1 in 60 persons who receive sibutramine.
Other important side effects include:
depression,psychosis,mania,suicidal thoughts andsuicide