How I sibutramine bodybuilding

How I sibutramine bodybuilding

Sibutramine

Sibutramine(Meridia) is considered being one of the best cures against excess weight. It possesses great potential and effectuality.Belonging to the class of appetite controllers, this cure easily regulates appetite sensations and effectively burns fats.

Sibutramine for bodybuilding

Bodybuilders report a noticeable appetite decrease when taking sibutramine in the mornings, and they are able to avoid cheat meals during the day.

However, since sibutramine was banned, it's more difficult for athletes to acquire this drug on the black market. As a result, sibutramine use has dropped significantly because athletes have instead turned to stimulants for appetite suppression.

How sibutramine works?

Unlike most other appetite suppressant drugs, sibutramine is not a releasing agent. It does not get inside the cells to boost the release of neurotransmitters, such as serotonin. Instead, as an uptake inhibitor, sibutramine works outside the cells to stop serotonin from being reabsorbed by the serotonin norepinephrine re-uptake receptors. This allows appetite control to last longer.

Sibutramine Dosage

Typically, the dose is taken in the mornings at 10 milligrams (mgs) per day, with or without food. If results are not adequate during the first 4 weeks, the user could increase the dose up to 15mgs per day.

Total length of use was several months or more, and, unfortunately, many users recovered weight once they stopped taking the drug.

For bodybuilders the same dosages applies. Though, there could be some variation due to size (weight).

Sibutramine effect

Reduces appetite and food intake (increases satiety), increases thermogenesis (due to indirect activation of β3-adrenergic receptors), has an impact on brown adipose tissue. In the body it forms active metabolites (primary and secondary amines), significantly superior to sibutramine in their ability to inhibit the reuptake of serotonin and norepinephrine.
The decrease in body mass is accompanied by an increase in the concentration of serum HDL and decreasing triglycerides, total cholesterol, LDL and uric acid. During treatment there is a slight rise in blood pressure alone (at 1-3 mm Hg. calendar) and a moderate increased heart rate (3-7 beats/min), but in rare cases, more pronounced changes.
After intake of rapidly absorbed from the gastrointestinal tract is not less than 77%. The “first pass” through the liver biotransformation influenced by the CYP3A4 isoenzyme of cytochrome P450 with the formation of two active metabolites (mono – and didemethylated).